List/Grid Tag Archives: ALK
Genetic Landscape of High-Risk Neuroblastoma
This newly published research paper, reporting findings from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) initiative, concludes that there are very few commonly recurring gene mutations amongst high-risk neuroblastoma patients. Aside from the previously discovered ALK mutation, this would mean there is limited scope for targeted therapy using DNA sequencing techniques ...
AACR 2011: A new antibody approach for neuroblastoma?
Anti-ALK antibody explored at Children’s Hospital of Philadelphia
An increasingly important research topic in neuroblastoma focuses on anaplastic lymphoma kinase (ALK) mutation or expression. At AACR there were 8 presentations on ALK and NB. While efforts are ongoing to better target the ~7% of NB cases that have an ALK mutation, now there is also compelling research on the ALK protein expression ...
AACR 2011 ~ 102nd meeting
The American Association for Cancer Research (AACR) is the oldest and largest scientific organization in the world focused on every facet of cancer research. AACR was founded in 1907 by 11 physicians and scientists interested in research with the goal to “to further the investigation and spread the knowledge of cancer.” Since then, the AACR has grown to 33,000 members and publishes seven ...
Antibodies and other bits
Big antibody news
The “third generation” humanized anti-GD2 antibody with protein fusion of IL2 to the antibody has completed Phase I and II clinical trials for melanoma and neuroblastoma, and is now ready for use in Phase III clinical trials. The license for hu14.18-IL2 was just acquired by a small biotech in Vienna called Apeiron. The license was acquired from Merck.
Apeiron’s press ...
Latest neuroblastoma related news
Neuroblastoma bits from November 2010
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Excellent new review article on anti-GD2 antibodies
Just published by Yang and Sondel, this thorough review tracks the evolution of antibodies for neuroblastoma through three generations: murine, chimeric, and humanized, and explains the of mechanisms for tumor kill and results of all prior trials. The summary details all combinations with cytokines, modifications ...
CNCF 2010 ~ 8th Annual Neuroblastoma Conference for Parents
Recap of presentations
I have so much more to report on ASCO and ANR (coming soon), but should share information about this conference first. This year’s conference was exceptional. The presentations covered a wide range of important topics, and I am convinced the 130 parents in attendance walked away with essential information for their families. This conference is extraordinary in that no rare ...
ANR 2010 ~ Days 1 & 2
History of ANR: Advances in Neuroblastoma Research
See photos posted on the ANR site! http://www.anr2010.com/photos/5166/Page.aspx
Dr Audrey Evans initiated this meeting in 1974, and interestingly, this was the same year she helped found the first Ronald McDonald House in Philadelphia. Approximately 50 researchers and clinicians participated in that first ANR meeting. There was one abstract submitted ...
