List/Grid Tag Archives: oncolytic virus
TWiPO #8 ~ Seneca Valley virus and medulloblastoma
TWiPO Episode 8
This Week in Pediatric Oncology Episode 8
Sponsored by Solving Kids’ Cancer (with NB Globe support). Posted with permission.
An oncolytic virus for a common childhood brain tumor
In this eighth episode of “This Week in Pediatric Oncology” podcast hosts Dr Tim Cripe, Dr Lars Wagner and Dr Lionel Chow discuss a recent publication by researchers at Baylor/Texas Children’s ...
Update on oncolytic virus trials for neuroblastoma
Four oncolytic virus trials open at Cincinnati Children’s for pediatric solid tumors
Dr Tim Cripe provided a very helpful comparison chart for the oncolytic virus trials currently open at Cincinnati Children’s, and permission to post it. To open a PDF of the chart, click on this link:
Viral study comparison (PDF document)
The chart lists the similarities and differences ...
Antibodies and other bits
Big antibody news
The “third generation” humanized anti-GD2 antibody with protein fusion of IL2 to the antibody has completed Phase I and II clinical trials for melanoma and neuroblastoma, and is now ready for use in Phase III clinical trials. The license for hu14.18-IL2 was just acquired by a small biotech in Vienna called Apeiron. The license was acquired from Merck.
Apeiron’s press ...
Webinar on oncolytic viruses for children
New clinical trials using oncolytic viruses for pediatric solid tumors
Solving Kids’ Cancer hosted a fantastic webinar on oncolytic viruses for children with solid tumors January 25, 2011.
All four principal investigators of five trials for children presented–starting with an overview given by Dr Tim Cripe:
Dr Michael Burke on Seneca Valley virus (NTX-101/SVV-001)
Dr Timothy Cripe on herpes ...
Latest neuroblastoma related news
Neuroblastoma bits from November 2010
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Excellent new review article on anti-GD2 antibodies
Just published by Yang and Sondel, this thorough review tracks the evolution of antibodies for neuroblastoma through three generations: murine, chimeric, and humanized, and explains the of mechanisms for tumor kill and results of all prior trials. The summary details all combinations with cytokines, modifications ...
Status on oncolytic virus therapies for pediatric solid tumors
A review of a new therapy for neuroblastoma
Significant and accelerating progress is underway in the oncolytic virus arena. In the past decade numerous clinical trials using several different oncolytic viruses against adult cancers have been completed and more are underway. Many trials have shown anti-tumor activity in various adult tumors. A major milestone was reached this year with three oncolytic ...
New oncolytic virus clinical trials listed
Three new oncolytic virus trials to treat neuroblastoma: vaccinia (JX-594), herpes simplex (HSV1716), and Newcastle Disease virus
Vaccinia JX-594
A Phase I, Open-Label, Dose Escalation Study of JX-594 (Vaccinia GM-CSF/Thymidine Kinase-Deactivated Virus) Administered by Intratumoral Injection in Pediatric Patients With Unresectable Refractory Solid Tumors
A phase I study using intratumoral injection ...
CNCF 2010 ~ Seneca Valley Virus NTX-010 is first oncolyic virus ever used in US children
Dr Michael Burke from the University of Minnesota is the Principal Investigator of the Seneca Valley Virus trial COG-ADVL0911:
“Seneca Valley Virus-001 in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features”
Dr Burke gave a presentation on this trial at the CNCF parent conference July 10, 2010.
By early July, ...
